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In pancreatic ductal adenocarcinoma, alanine is utilized by stroma-associated pancreatic stellate cells to fuel the citric acid cycle, as well as non-essential amino acids and lipid biosynthesis in tumor cells, being protumor in this context [87]

Moreover, pre-treatment with anti-MET antibodies blocked the beneficial effect exerted by HGF, while the one exerted by MSCs was blocked by anti-HGF antibody, showing that the positive effect was mostly dependent on the production of HGF

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In contrast, in ethanol-exposed Grx1 -deficient mice, accumulation of FAS-SSG drives hepatocyte apoptosis through dysregulation of NF-B and AKT serine/threonine kinase 1 (AKT1) signaling 47